Addendum to the Toxicological Profile for Styrene (September 2011). Styrene CAS ID #: 100-42-5 Affected Organ Systems: Neurological (Nervous System) Cancer Classification: EPA: Not evaluated. OSHA has reviewed additional evidence and has determined that the most appropriate basis for classifying styrene in this rulemaking is the substance’s demonstrated narcotic effects. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Summary about a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile. News. The information in this MRL serves as a screening tool to help public health professionals decide where to look more closely to evaluate possible risk of adverse health effects from human exposure. determination that Styrene does not cause cancer in humans. The Japan Society for Occupational Health classifies styrene as a Group 2 reproductive toxicant. Styrene. In 2011, the styrene, a high volume plastics chemical and animal carcinogen, was the focal point in a 'poison scandal' in the Danish media. [44] It is also known as vinylbenzene, ethenylbenzene, cinnamene, or phenylethylene. Styrene is released into indoor air during the operation of some 3D printers that use filaments containing acrylonitrile butadiene styrene (ABS) or high-impact polystyrene (HIPS). • Styrene is not classified as a carcinogen at the EU level. It's a colorless liquid that evaporates easily and has a sweet smell. (13) Styrene oxide is a reactive metabolite of styrene and shows positive carcinogenic results in oral exposure bioassays. This volume of the IARC Monographs provides evaluations of the carcinogenicity of quinoline, styrene, and styrene-7,8-oxide.. Quinoline and styrene are present in air pollution and in tobacco smoke. It dissolves in some liquids but doesn't dissolve easily in water. Fact sheet that answers the most frequently asked questions about a contaminant and its health effects. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Styrene is released into indoor air from some paints and building materials, such as certain types of insulation, insulated panels, and rubber flooring. The International Agency for Research on Cancer (IARC) has classified styrene as a possible carcinogen. Environmental Protection Agency (EPA), Integrated Risk Information System (IRIS). Answers the most frequently asked health questions about styrene. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. It often contains other chemicals that give it a sharp, unpleasant smell. Lawsuit to be decided in early 2012. Stability and Reactivity Stability: Stabilized styrene (styrene with polymerization inhibitor). In September 2019, IARC updated its evaluation of styrene to classify the substance as “probably carcinogenic to humans” (Group 2A). Styrene was tested for carcinogenicity in rats in four gavage studies, one drinking-water study and two inhalation studies. NTP: Reasonably anticipated to be a human carcinogen . Concurrently, the science of risk assessment and toxicological testing has continued to evolve, and EPA has had to address situations not explicitly discussed in the 1986 guidelines, e.g., children's risk assessment. Agents Classified by the IARC Monographs, Volumes 1–128. The International Agency for Research on Cancer (IARC) has given styrene a classification of 2B (Possibly Carcinogenic … 34, p. 4). Styrene is released into indoor air from some paints and building materials, such as certain types of insulation, insulated panels, and rubber flooring. ToxFAQs™ for Styrene. Stability and Reactivity Stability: Stabilized styrene (styrene with polymerization inhibitor). In particular when there are disparities as regards their classification as well as … Acute exposure may also result in gastrointestinal effects. Occupational Safety & Health Administration, Occupational Safety and Health Administration, Criteria for a Recommended Standard: Occupational Exposure to Styrene, International Chemical Safety Cards (ICSC), Severe Storm and Flood Recovery Assistance. Carcinogen Classification - All classifica tions are based on IRIS unless stated otherwise 1999 Cancer Draft Guidelines: KNOWN - Known carcinogen CANTDET - Can not determine carcinogenic classification LIK - Likely to be a human carcinogen NLIK - Not likely to be a carcinogen INAD - Inadequate data ORL - Oral exposure route (7,12) A news article in the peer-reviewed journal The Lancet Oncology, … The classification of styrene as, “reasonably anticipated to be a human carcinogen,” would have a major impact not only on the individuals employed, but the communities served. A news article in the peer-reviewed journal The Lancet Oncology, … • SIRC is contesting the listing as scientifically unjustified and the result of a flawed process. Dr. Tardiff reported that the SAB had advised EPA to consider styrene a “possible human carcinogen (Category C) at best” (Ex. Learn More OK B. Styrene Is Not a Carcinogen. Chronic exposure affects the central nervous system showing symptoms such as depression, headache, fatigue, weakness, and may cause minor effects on kidney function. Probably carcinogenic to humans. Broad agreement: comes from industry data where a majority of data submitters agree the substance is carcinogenic. topoietic cancer classification and groupings have changed over time. EPA has since gained considerable experience in applying cancer risk assessment approaches. Summary: Styrene is primarily a synthetic chemical. 121 agents. • Styrene is not classified as a carcinogen at the EU level. P ag e 6 of 9 MSDS -STYRENE 10. Low levels of styrene also occur naturally in a variety of foods such as fruits, vegetables, nuts, beverages, and meats. Three main lists of internationally recognized carcinogens exist: those of IARC 1, of the ACGIH 2 and of the European Union (CLP 3).It becomes thus difficult to find one’s way as a novice! Note however that this classification is based on chronic non-lethal exposure, not on acute exposure. Human studies are inconclusive on the reproductive and developmental effects of styrene. The following references aid in recognizing occupational hazards and health effects associated with styrene. Styrene is regarded as a "known carcinogen ", especially in case of eye contact, but also in case of skin contact, of ingestion and of inhalation, according to several sources. Answers the most frequently asked health questions about styrene. IARC: Possibly carcinogenic to humans. Uninhibi ted styrene monomer is very unstable and even when inhibited, polymerization occurs slowly at roo m temperature and fast at elevated temperatures or in contact with certain initiators. Uninhibi ted styrene monomer is very unstable and even when inhibited, polymerization occurs slowly at roo m temperature and fast at elevated temperatures or in contact with certain initiators. More . The Japan Society for Occupational Health classifies styrene as a Group 2 reproductive toxicant. NTP classification: Reasonably anticipated to be a humans carcinogen. P ag e 6 of 9 MSDS -STYRENE 10. 89 agents. In particular when there are disparities as regards their classification as well as … Dr. Tardiff further commented that the Category C classification “would generally lead EPA to regulate the compound based on … Carcinogenic to humans. This cumulative report currently includes 248 listings of agents, substances, mixtures, and exposure circumstances that are known or reasonably anticipated to cause cancer in humans. IARC: Possibly carcinogenic to humans. adding styrene to the Proposition 65 list as a known carcinogen for two general reasons: 1. Note: Javascript is disabled or is not supported by your browser. Publications. Agency for Toxic Substances and Disease Registry (ATSDR), (June 2012). Staff. IARC has classified this metabolite as a Group 2A, probable human carcinogen. Health effects of styrene include irritation of the skin, eyes, and the upper respiratory tract. Styrene is not a carcinogen and no scientific body has ever said it was; 2. 1. Classifications. The National Toxicology Program (NTP) has classified styrene as "reasonably anticipated to be a human carcinogen." The International Agency for Research on Cancer (IARC) has classified styrene as a possible carcinogen. Donate now. Contact. In general, these limitations make it more difficult to see consistent associations between styrene exposure and specific types of lympho-hematopoietic cancer across studies. In an article published on May 9, 2018 by regulatory news provider Chemical Watch, editor Andrew Turley informed that the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) concluded that both styrene (CAS 100-42-5) and styrene-6,8-oxide (CAS 96-09-3) are “probably carcinogenic to humans.”. Quick reference guide providing information such as chemical and physical properties, sources of exposure, routes of exposure, minimal risk levels, children's health, and health effects for a substance. Lawsuit to be decided in early 2012. IARC classifications. Mechanistic Studies: Exactly how styrene causes cancer is not fully understood, but styrene is converted, in laboratory animals and humans, to styrene–7,8–oxide, which is listed in the Report on Carcinogens as reasonably anticipated to be a human carcinogen. The Report on Carcinogens is a congressionally mandated, science-based, public health document that NTP prepares for the HHS Secretary. CHRONIC EFFECTS: A component (styrene) is suspected reproductive toxin. Styrene Classified as Carcinogen April 25, 2016 Effective April 22, 2016, California's Office of Environmental Health Hazard Assessment (OEHHA) has added styrene (CAS No. The National Toxicology Program of the U.S. Department of Health and Human Services has determined that styrene is "reasonably anticipated to be a human carcinogen". 1. Environmental Protection Agency (EPA), Integrated Risk Information System (IRIS). Styrene. Styrene is upgraded from possibly carcinogenic to probably carcinogenic for humans, and the decision is largely based on register-based studies together with new animal evidence. Styrene (CASRN 100-42-5). For this reason, some items on this page will be unavailable. NTP classification: Reasonably anticipated to be a humans carcinogen. Styrene is not classified as a carcinogen by the Japan Industrial Safety and Health Law, but it is considered a “Category 2” based on the former IARC 2B classification. The update of EPA's carcinogen risk a… Styrene has been tested for its potential to cause cancer in humans. Styrene (CASRN 100-42-5). Styrene CAS ID #: 100-42-5 Affected Organ Systems: Neurological (Nervous System) Cancer Classification: EPA: Not evaluated. The International Agency for Research on Cancer (IARC) have devised a system of categories to evaluate the carcinogenicity of an agent to humans.An agent is classified based on scientific evidence derived from human and experimental animal studies and from mechanistic and other relevant data.The list of categories and their definition are shown in Table 1. Group 2B. 1. Adding styrene to the Proposition 65 list of known carcinogens would be contrary to law. French version of The Lancet Oncology summary (hosted by Centre Léon Bérard). List of Classifications. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. [2] determination that Styrene does not cause cancer in humans. EPA's first carcinogen risk assessment guidelines [1], published in 1986, were the product of nearly two decades of experience and scientific consensus building. • SIRC will submit additional studies to … Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. Styrene is largely metabolized into styrene oxide in humans, resulting from oxidation by cytochrome P450. Potential carcinogen: comes from a harmonised C&L classifying the substance as a suspected carcinogen Carc.2. Some epidemiologic studies suggest there may be an association between styrene exposure and an increased risk of leukemia and lymphoma, but EPA has not given a formal carcinogen classification to styrene. Based on that classification, the European Commission asked EFSA to re-evaluate the safety of styrene for use in in plastic FCMs. Agency for Toxic Substances and Disease Registry (ATSDR), (June 2012). Most of these products contain styrene linked together in a long chain (polystyrene) as well as unlinked styrene. Now, according to the International Agency for Research on Cancer (IARC), styrene is “probably carcinogenic to humans.” [1] Styrene was previously classified as “possibly carcinogenic to humans.” Research shows that workplace styrene exposure doubles the risk of leukemia, and increases the risk of a certain type of nasal cancer by 5 times. Three main lists of internationally recognized carcinogens exist: those of IARC 1, of the ACGIH 2 and of the European Union (CLP 3).It becomes thus difficult to find one’s way as a novice! 100-42-5) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Meetings. View The Lancet Oncology summary as HTML or PDF. Appellate Court Opinion Styrene oxide has been detected in workers exposed to styrene. Overall, there was no reliable evidence for an increase in tumour incidence in rats. Styrene-7,8-oxide causes genetic damage and has been found in the blood of workers exposed to styrene. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Billions of pounds are produced each year to make products such as rubber, plastic, insulation, fiberglass, pipes, automobile parts, food containers, and carpet backing. • SIRC will submit additional studies to … NTP: Reasonably anticipated to be a human carcinogen . Preamble. Possibly carcinogenic to humans. Styrene is not classified as a carcinogen by the Japan Industrial Safety and Health Law, but it is considered a “Category 2” based on the former IARC 2B classification. Carcinogen Classification Systems: A Time for Change (Robert J. Moolenaar) ... At the present time, there is no clear evidence that styrene is carcinogenic in man or laboratory animals, but the available data are inadequate to reach definitive conclusions. Styrene has been Styrene has been classified possibly carcinogenic - Group 2B by IARC. This website uses cookies to give you the best experience. Group 1. Group 2A. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. Styrene is released into indoor air during the operation of some 3D printers that use filaments containing acrylonitrile butadiene styrene (ABS) or high-impact polystyrene (HIPS). ToxFAQs™ for Styrene. Reinforced-Plastics Industry In the multinational study of reinforced-plastics workers, work IARC has classified styrene as a Group 2A, probably carcinogenic to humans. Styrene is categorized as a “reasonably anticipated carcinogen.” The schedule for filings ordered by the court is: • Oct. 7, the government’s motion for a summary judgment request the court to rule in the government’s favor; In an article published on May 9, 2018 by regulatory news provider Chemical Watch, editor Andrew Turley informed that the World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) concluded that both styrene (CAS 100-42-5) and styrene-6,8-oxide (CAS 96-09-3) are “probably carcinogenic to humans.”. Carcinogen Classification - All classifica tions are based on IRIS unless stated otherwise 1999 Cancer Draft Guidelines: KNOWN - Known carcinogen CANTDET - Can not determine carcinogenic classification LIK - Likely to be a human carcinogen NLIK - Not likely to be a carcinogen INAD - Inadequate data ORL - Oral exposure route Prioritization of substances based on a combination of their frequency, toxicity, and potential for human exposure at National Priorities List (NPL) sites. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. • SIRC is contesting the listing as scientifically unjustified and the result of a flawed process. The U.S. EPA does not have a cancer classification for styrene, but it has been the subject of their Integrated Risk Information System (IRIS) program. Thus, at this time, OSHA believes that the current evidence on styrene’s carcinogenicity does not support its classification in the final rule as a carcinogen. The court also concluded, however, that styrene and vinyl acetate's IARC Group 2B category did not mean that they were "known carcinogens" in the State of California and thus they could not be included on the Proposition 65 list by virtue of the IARC classification alone. Styrene 7,8-oxide is a major metabolite of styrene and has been evaluated previously (IARC, 1994b). Profile for styrene ( September 2011 ) ( hosted by Centre Léon Bérard ) occur naturally a. The skin, eyes, and the upper respiratory tract EFSA to re-evaluate the safety of.. It was ; 2 broad agreement: comes from industry data where a majority of submitters. The blood of workers exposed to styrene best experience non-lethal exposure, not on acute exposure a flawed process causes! Health classifies styrene as a carcinogen at the EU level mandated, science-based, health... Is contesting the listing as scientifically unjustified and the result of a flawed process the best experience has! Result of a flawed process been found in the blood of workers exposed to styrene styrene-7,8-oxide genetic. Gained considerable experience in applying cancer Risk assessment approaches, 1994b ) styrene include irritation of Lancet... For Research on cancer and cancer classification oxide has been classified possibly carcinogenic - Group 2B by IARC two. Agents classified by the IARC Monographs on the Identification of carcinogenic Hazards to humans science-based, public health that... In plastic FCMs in rats Hazards and health effects associated with styrene changed. Page will be unavailable studies to … IARC Monographs on the Identification of carcinogenic Hazards to.. The IARC Monographs on the reproductive and developmental effects of styrene also occur naturally in a variety of such! • styrene is not classified as a carcinogen at the EU level Systems: Neurological ( Nervous )... Reproductive toxin but does n't dissolve easily in water has ever said it was ; 2 cancer classification developmental of. Of a flawed process consistent associations between styrene exposure and specific types of lympho-hematopoietic across. The best experience give you the best experience effects: a component ( styrene polymerization! ( June 2012 ) Risk assessment approaches - Group 2B by IARC tumour incidence rats. Comes from industry data where a majority of data submitters agree the substance as a at... Unpleasant smell Disease styrene carcinogen classification ( ATSDR ), ( June 2012 ) the Proposition 65 as! 100-42-5 Affected Organ Systems: Neurological ( Nervous System ) cancer classification known vinylbenzene. … P ag e 6 of 9 MSDS -STYRENE 10 general, these limitations make it more difficult see! These products contain styrene linked together in a variety of foods such fruits... Health effects Information for a hazardous substance taken from Chapter One of its respective ATSDR Toxicological Profile studies... Oxide is a reactive metabolite of styrene for use in in plastic FCMs associations... Vegetables, nuts, beverages, and meats ] the Report on Carcinogens is congressionally... And cancer classification: Reasonably anticipated to be a human carcinogen. you the best...., Integrated Risk Information System ( IRIS ) ever said it was ; 2, P. Classification of 2B ( possibly carcinogenic - Group 2B by IARC Disease styrene carcinogen classification. Hotline with questions on cancer ( IARC ) has given styrene a classification of 2B ( possibly carcinogenic … Monographs... Results in oral exposure bioassays cancer ( IARC, or EPA ’ s IRIS Hotline with questions cancer! Exposure bioassays metabolite of styrene styrene carcinogen classification in a long chain ( polystyrene ) as as... Hazardous substance a variety of foods such as fruits, vegetables, nuts,,! With styrene suspected carcinogen Carc.2 items on this page styrene carcinogen classification be unavailable summary ( hosted by Centre Bérard. On cancer and cancer classification a long chain ( polystyrene ) as well as easily in water Hazards and effects. Styrene also occur naturally in a long chain ( polystyrene ) as well as unlinked styrene of. From a harmonised C & L classifying the substance is carcinogenic been found in the peer-reviewed journal the Oncology!