You should talk with your health care provider for complete information about the risks and benefits of using this product. Avoid use; red clover has estrogenic activity. Medieval Christians associated the three leaves as a resemblance to the Holy Trinity and sought to use it in many aspects of diet and additives. This product may be unsafe when used before surgery or other medical procedures. The reports note heterogeneity among the clinical studies and a high risk of bias; a strong placebo effect (range, 1% to 59%) was also found.21 No adverse effects were reported over 2 years, including no evidence of estrogenic stimulation of endometrium or vaginal tissue.21 A 2016 systematic review (n=10) and meta-analysis (n=6) of randomized controlled trials found red clover to be more likely to result in significant reductions in hot flashes for women with lower estrogen levels (ie, postmenopausal women) and for women with at least 5 hot flashes/day. Keep in mind that natural products are not always necessarily safe and dosages can be important. Decreases of 70% were found for depression and anxiety compared with baseline. Studies show some benefits to incorporating red clover extract into your daily routine. Select one or more newsletters to continue. The major isoflavones in red clover are biochanin A, formononetin, daidzein, and genistein; total phytoestrogen content is approximately 0.17%.1, 2, 3, 4, Much of the interest in red clover originated from observations of positive health benefits derived from the use of soy products. Red clover supplements can be found in standardized extract form or capsules. Total scores improved 10.33 points with red clover compared to 3.57 with placebo (P = 0.0001). This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Red clover is available in various forms, including powder form. Isoflavonoids may interfere with hormonal agents; avoid use with oral contraceptives, estrogen, or progesterone therapies. Red clover has no known serious interactions with other drugs. A volatile oil that includes methyl salicylate is distilled from the flowers.3 Isoflavones are often termed "phytoestrogens" because of their functional similarity to estrogens. Red Clover has been used for hundreds of years for its purported health benefits. Safety of use in treating breast cancer has not been determined, and the epidemiological association of isoflavone consumption in protecting against prostate cancer has not yet been confirmed by clinical trials. If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Red clover supplementation is not advised in children younger than 12 years.1, 9, 36. Standardized commercially prepared isoflavins. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. Red clover is a nutrient-dense herb that is best extracted with water. Avoid use. The red clover is easily identified by its reddish-pink globe-like flower, hairy stems, and unique “V” mark coloring on the three-lobed leaves. It is not known if red clover has any effect on the risk of developing, Preliminary evidence suggests a reduction in, More studies are needed to determine whether Red clover is effective in treating. However, results from studies of red clover have been mixed, with only some demonstrating modest improvements in lipid profile.11, 12, 13, 14, 15 Many small studies found decreased LDL and increased high-density lipoprotein,9, 16, 17 but a larger study (N = 401) reported no effect on lipid profile in menopausal women.18 However, significant improvements in both LDL (P = 0.005) and total cholesterol (P = 0.015) were seen in menopausal women who consumed red clover isoflavone 25 mg twice daily (predominantly formononetin and biochanin) for 2 years, compared with those who took placebo in a randomized, double-blind, placebo-controlled study (n = 147). Our Red Clover is organically grown by Trout Lake Farm, Washington, and certified organically processed by Oregon Tilth. Phytoestrogens have a … The phytoestrogens in red clover may be expected to act through estrogenic mechanisms with the associated risk of estrogen-like adverse effects, including increased incidence of endometrial, ovarian, and breast cancers36; however, whether phytoestrogens are beneficial or harmful to human health is unresolved.43 Red clover induced a proliferation of estrogen-sensitive breast cancer cells in an in vitro study.36, 44 Infertility and growth disorders have been observed in grazing animals, including sheep receiving high proportions of red clover in their feed. Few adverse effects of red clover have been reported in clinical trials at doses of up to 160 mg isoflavones per day.1, 34, 41 Loss of appetite, pedal edema, and abdominal tenderness have been reported after high doses of isoflavones (4 or 8 mg/kg).42 Free and total genistein and daidzein disappeared rapidly from the plasma in this study and are unlikely to accumulate in the body with regular use of 2 to 3 times daily. No side effects were observed.52, The Society of Obstetricians and Gynaecologists of Canada revised clinical practice guidelines on managing menopause (2014) recommend that complementary and alternative medicine that has demonstrated efficacy for mild menopausal symptoms, including products containing isoflavones sourced from red clover, may be offered by health care providers (Level I-B).54 The Endocrine Society clinical practice guidelines for the treatment of symptoms of the menopause (2015) recommend counseling patients on the lack of consistent evidence for benefit of complementary medicine therapies, including red clover, as an alternative nonhormonal therapy for vasomotor symptoms (weak recommendation; low quality evidence).55, In ovariectomized rats, red clover restored the pain threshold to levels matching those of the animals in the control group (intake ovary).27, Secondary outcomes of some clinical trials have included effects on CNS symptoms in postmenopausal women. A reduction of 22% was found for the placebo.28 Another study (N = 66) reported no effect of 120 mg of red clover isoflavones on any cognitive measures in postmenopausal women.29 However, a randomized, triple-blind, placebo-controlled trial in 72 postmenopausal Iranian women with a BMI up to 28 documented significant improvements in menopausal symptom scores for women who received red clover capsules daily (80 mg/day dried leaves) for 12 weeks compared to placebo. Red clover studies were reviewed that pertained to women's health or menopause. What is Red Clover Extract (Trifolium pratense)?Red clover extract (Trifolium pratense) is taken from an herbaceous flowering perennial that is native to Europe, Asia, and Africa. The availability of clinical trial data and systematic reviews of red clover in menopause-related osteoporosis makes animal data less relevant. There is no reference nutrient intake (RNI) for red clover but in a three-year trial, scientists gave high-dose treatments of up to 120mg a day with no ill-effects.9 However, because red clover contains phytoestrogens, avoid taking it if you have breast cancer or another hormone-sensitive cancer. Red clover is now used primarily as a source of isoflavones. Several commercial preparations are available. Clinical trials have used higher doses (160 mg/day); however, long-term safety of such doses has not been established.21 Crude plant extract 240 mg approximates to 40 mg of isoflavones.1 Several commercial preparations are available. It is often used as a nourishing herbal infusion, using 1 ounce of dry herb infused in a quart of just-boiled water. Medically reviewed by Drugs.com. Find patient medical information for Red Clover Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This information does not contain all possible interactions or adverse effects. Keep out of reach of children. Red clover has no known severe interactions with other drugs. Trifolium pratense c… A clinical trial using a crossover design was conducted with 109 women given 80 mg of red clover isoflavones or placebo for 90 days. Red clover (Trifolium pratense) is a flowering plant.Like chickpeas and beans, it’s a legume. Case reports are lacking; however, caution is warranted with concomitant use of tamoxifen or letrozole. Red clover blossoms for sedation were formerly used at doses of 4 g, but are now used primarily as a source of isoflavones. Vitamin D Deficiency: How Much Vitamin D Is Enough? This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. The extract was standardized to 33.78 mg/day aglycones and given as 37.1 mg/day for 12 weeks. Note, however, that research hasn't shown that the herb is conclusively effective for these or any other health concerns. Red Clover Preparations and Dosage Red Clover can be ingested in a number of ways. These effects have been attributed to the estrogenic activity of red clover.2 One report suggests that this estrogenism disease state is more likely to occur with Trifolium subterraneum than with Trifolium pratense.45. Phytoestrogens appear to act as partial agonists in some tissues and antagonists in others, exhibiting hormonal and nonhormonal properties.6 They have a greater affinity for beta-estrogen rather than alpha-estrogen receptors. While dosage depends on what you’re using it for, recommendationsare as follows: 1. Red Clover Extract Supplement. The phytoestrogens in red clover may be expected to act through estrogenic mechanisms, with the associated risk of estrogen-like adverse effects, including increased incidence of endometrial, ovarian, and breast cancers. An Introduction to Red Clover Dosage Red clover (Trifolium pratense) is an herbal supplement that is typically used for natural menopause relief.Unlike medications (for which the standard doses have been well established in carefully designed studies), there is less information available about the best dosage for herbal supplements, including red clover. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Formerly used as a sedative at doses of 4 g blossoms, red clover is now used chiefly as a source of isoflavones. The globular heads of reddish-purple flowers have long been prized by herbalists. The flower is a mainstay ingredient in traditional herbal formulas, including Essiac Tea, Jason Winters Tea, and the Hoxsey Therapy. Formerly used as a sedative at doses of 4 g blossoms, red clover is now used chiefly as a source of isoflavones. Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns or for more information about this medicine. However, there is no clinical evidence to support any of these uses or for use in menopause-related conditions. Historically, red clover was used for asthma, whooping cough, cancer, and gout. Red clover blossoms for sedation were formerly used at doses of 4 g, but are now used primarily as a source of isoflavones, plant substances that can have healing effects. A nonsignificant mean difference of −0.93 (95% confidence interval [CI], −1.95 to 0.1) was found for red clover alone in reducing the incidence of hot flushes versus placebo, and a nonsignificant mean difference of 20.15% (95% CI, −12.1 to 52.4) was reported for reduction of hot flushes.21, For all phytoestrogens (7 trials), a nonsignificant effect was noted using the Kupperman Index. What Are Warnings and Precautions for Red Clover? The use of red clover as an herbal remedy goes back centuries, and the plant enjoys a history of both topical and internal applications. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind). Eczema, psoriasis, and rashes all respond to its soothing and healing qualities. Are there any side effects of using red clover? Red clover flowers have been used traditionally as a sedative, to purify the blood, and to treat respiratory conditions; topical preparations have been used for psoriasis, eczema, and rashes, and to accelerate wound healing. Moderate interactions of red clover include: Red clover has no known mild interactions with other drugs. Do not take Beebread, Cow Clover, Meadow Clover, Purple Clover, Trefle Des Pres, Trefoil, Trifolium pratense, or Wild Clover if you are allergic to red clover or any ingredients contained in this drug. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Next to red peppers, you can get the most vitamin C from ________________. Mean vegetative somatic scores (eg, hot flushes, heart discomfort, sleeping disorders) were significant (P = 0.002). The usual therapeutic dosage is 3 to 4 cups a day. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Red clover is available under the following different brand names: Beebread, Cow Clover, Meadow Clover, Purple Clover, Trefle Des Pres, Trefoil, 1 cup orally three times daily; 4 g flower tops/150 ml, 1.5-3 ml orally three times daily; 1:1 in 25%, 1-2 ml orally three times daily; 1:10 in 45% alcohol, Isoflavones extract: 40-160 mg/day orally, See "What Are Side Effects Associated with Using Red Clover? Although, a mean difference of 0.89 (95% CI, 0.26 to 1.52) was found for reduction in hot flushes compared with placebo for 10 studies.23, For red clover given over 3 to 4 months, a mean difference in hot flush frequency of −1.34 (95% CI, −1.9 to 0.77) was reported, whereas over 12 months, a nonsignificant difference was reported (0.89 [95% CI, −0.07 to 1.85]).22, The 3 meta-analyses,21, 22, 23 as well as other systematic reviews,1, 24, 25, 26 concluded that there is no compelling evidence of red clover efficacy in managing the vasomotor symptoms of menopause. Doses of red clover are standardized from 40 mg to 80 mg of isoflavones (the active ingredient in red clover) per 24 hours is often recommended. Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. 80 mg of isoflavones can be administered as an isolated compound or as red clover extract. In a small clinical trial (N = 23), red clover 86 mg/day isoflavone had no effect on homocysteine,19 while women receiving 40 to 80 mg daily of red clover isoflavones in another trial (N = 43) experienced decreased insulin sensitivity.20. Genistein content may negate the effects of tamoxifen and aromatase inhibitors such as letrozole.26, Red clover contains disputed amounts of coumarin derivatives (including coumarin, medicagol, and coumestrol); however, the risk of anticoagulant abnormalities is low.1, 3, 37, 38, 39 A case report of bleeding exists; however, the patient was taking a combination preparation that included dong quai and Siberian ginseng, as well as red clover.40, Contraindicated in patients with hormonal disorders or estrogen-dependent breast cancer (or risk of), and during pregnancy or lactation. This medication contains red clover. Red clover is a member of the bean family, with early descriptions using it as a main food source for cattle. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Red Clover is mainly used for its blood cleansing abilities, making it great for addressing skin conditions. Red clover contains substances called isoflavones. Because red clover thins the blood, those with blood-clotting abnormalities should probably not take this supplement. There is a lot of poor quality red clover on the market. The median lethal dose in mice is estimated to be approximately 4 g/kg intraperitoneally.3 As a flavor or seasoning, Trifolium species are GRAS classified under the Federal Food, Drug, and Cosmetic Act.3. When supplementing with red clover extract powder, take 1,500 mg daily with food or water. If possible, harvest and dry your own to get the best quality. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. For general supplementation: Drugs.com suggests using a daily dose of 40 to 120 mg of isoflavones per day (from soy) or 40 to 80 mg per day of isoflavones (from red clover) for various conditions. It is advisable to have 2 of them a day for achieving results in a bust augmentation. Recommended dosage, active amounts, other details Supplementation of … It has a taproot, unlike other clovers that have a creeping root system. More studies are needed. No side effects were observed.52, Changes in sexual symptoms were not found to be significantly different between the red clover and placebo groups in 3 of 4 studies reviewed systematically; one study, however, reported significant decreases in dyspareunia and low libido with administration of red clover compared to placebo (P<0.05). A systematic review of studies of the effect of red clover and risk of breast cancer suggests that at doses similar to those of a traditional Japanese diet (25 to 50 mg isoflavones), no risk is posed to breast cancer survivors. What Are Side Effects Associated with Using Red Clover? See additional information. It has al… Arterial compliance, an index of the elasticity of large arteries, improved in a small, short-term study of postmenopausal women receiving red clover.13 These results were confirmed by a larger study of normotensive men and postmenopausal women.15 Ambulatory blood pressure remained unchanged, but total peripheral resistance improved in these patients. The estrogenic effects of red clover are well documented and may have an effect on the fetus. This perennial herb is commonly found in light, sandy soil in meadows throughout Europe and Asia. In contrast, a reverse effect was seen in women experiencing at least 3 hot flashes/day. The red clover plant contains a wide array of vitamins and minerals. Most 500 mg extracts contain 40 mg of isoflavones. Red clover does not significantly reduce total or LDL cholesterol, or increase HDL in women 49-65. Available for Android and iOS devices. Red clover dosage. The availability of clinical trial data and meta-analyses of red clover in menopause makes animal data less relevant. If you feel that you are having any other health problems or are taking other medications, you should consult with your doctor before you take red clover. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Clinical trials, including those done with postmenopausal women, have used varying red clover dosages to safely produce positive effects. In alternative medicine, red clover is said to help with the following conditions. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. However, the reviewers note the need for more evidence of safety at doses greater than 100 mg/day of isoflavones.46 Another systematic review and meta-analysis of 8 clinical trials found no effect of isoflavones on breast density in postmenopausal women, but some evidence of increased density in premenopausal women (mean difference, 1.83% [95% CI, 0.25% to 3.4%]).47 The reviews include a study that found mammographic breast density to be unaffected by 40 mg daily of red clover isoflavones for up to 3 years in women who had at least 1 first-degree relative with breast cancer (N = 401).22 No change in endometrial thickness or follicle-stimulating hormone levels has been reported.18, 48, 49 A study not included in the reviews, reported that use of red clover among 1,183 breast cancer survivors resulted in fewer reports of weight gain, night sweats, or difficulty in concentration.50 None of the botanical products used by these women were associated with health-related quality of life measures, fatigue, or hormonally related symptoms. Red Clover herb is a simple to find herb with many uses. Exceeds Cal. ", Avoid use of red clover during pregnancy or while. Weak estrogenic activity has been demonstrated in rats.7 Several nonhormonal mechanisms have also been demonstrated, including tyrosine kinase inhibition, antioxidant activity, and effects on ion transport.8, The availability of clinical trial data of red clover in cardiovascular conditions makes animal data less relevant; however, experiments in animals suggest an atheroprotective effect via low-density lipoprotein (LDL) reduction.9, 10, Beneficial effects of soy protein on blood lipid profiles have been demonstrated. Our Red Clover contains only the full Clover Blossoms and their accompanying leaves. Medscape - Indication-specific dosing for beebread, cow clover, meadow clover, purple clover, trefle des pres, trefoil, trifolium pratense, wild clover (red clover), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Total scores improved 10.33 points with red clover compared to 3.52 with placebo (P = 0.0001). This information should not be used to decide whether or not to take this product. With the exception of vaginal dryness, no significant improvement was seen in urogenital subcategory scores; however, mean vegetative somatic scores (eg, hot flushes, heart discomfort, sleeping disorders) and differences in mean psychological scores (eg, anxiety, irritability, physical and mental exhaustion) were significant (P = 0.002, P = 0.0001, respectively). Dense terminal heads with up to 125 fragrant flowers are borne at the end of the branched stems. 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